Paralyzed and confined to an iron lung since childhood, poet-journalist Mark O'Brien (Hawkes) has overcome adversity time and time again. But now, at age 38, he faces his toughest challenge yet: losing his virginity. With the help of a beautiful therapist (Hunt), a sympathetic priest (Macy), and his own unbridled sense of optimism and humor, Mark embarks on an extraordinary personal journey to discover the wondrous pleasures that make life worth living.